Yes, if you plan to fly the drone for anything other than recreational purposes (under the authority of 14 CFR 107) then you will need to obtain a drone pilot license. The FAA created a separate drone pilot license (called a remote pilot certificate) for anyone piloting a drone under the Part 107 rule. The remote pilot certificate can be obtained by taking and passing an aeronautical knowledge test. However, anyone who holds a part 61 pilot certificate and has completed a flight review within the past 24 months may obtain the new remote pilot certificate by taking an online training course that focuses on drone-specific areas of knowledge instead sitting for the knowledge test. Everyone else will be required to take and pass the initial aeronautical knowledge test to obtain a remote pilot certificate.
The only other exceptions to the above would be drone operations under a Section 333 waiver and drone operations under a public COA.